VDR is a gene which encodes a protein that acts as a receptor vitamin D, which regulates bone development and calcium absorption. A variant of the gene known as the rs2228570 (FokI polymorphism), is associated with decreased bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern as well as the temporal on-and-off occupancy of VDRE between the two components. It is also modulated by chromosomal positioning and binding preferences for certain hormones. Microarray studies on human cells have revealed that more than 100 genes have a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository of data and documents pertinent to legal, business transactions or proceedings with restrictions on viewing printing, downloading, or viewing. It makes use of a central server and an extranet connection which is an Internet connection that has restricted access, to provide controlled log-on for set intervals during which users can view the data and documents.
Companies that deal with investment bankers and in mergers and acquisitions are the most common users of a VDR. They need a secure platform for sharing information with potential buyers or investors in a manner that is transparent, and due diligence can require massive click to read quantities of data. Life science companies also utilize VDRs to store everything from clinical trials results to HIPAA documentation.